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  • Pleasant Valley Corporation Forms Strategic Partnership With Major Facility Management Provider, Dexterra Group, to Expand Services Across North America

    Pleasant Valley Corporation Forms Strategic Partnership With Major Facility Management Provider, Dexterra Group, to Expand Services Across North America

    MEDINA, OHIO / ACCESS Newswire / July 31, 2025 / Pleasant Valley Corporation (PVC)-a leading U.S. facility, construction and real estate services provider headquartered in Medina, Ohio-has formed a strategic partnership with Canadian facility management company, Dexterra Group Inc. (TSX:DXT). Through a minority equity investment in PVC, Dexterra is positioned to expand service capabilities and geographic reach across North America.

    For PVC, the partnership with Dexterra represents a complementary match. Dexterra’s strength in self-performing maintenance and extensive background in both public and private sector support services, including complex contracts like public-private partnerships (P3), will be a significant benefit to PVC clients.

    PVC’s distributed service model, which incorporates a proprietary facility management technology, PVC Connect™, along with its quality vendor network and service to long-standing client relationships that include Fortune 500 companies, will add significant scale and layers of capabilities to the partnership across North America.

    Both companies will benefit from shared industry knowledge, greater resources, and strategic alignment-enhancing services for clients and creating new growth opportunities for employees.

    Founded in 1976 by co-CEOs Barbara and Gino Faciana, PVC offers a full range of facility services, including integrated facility management. The company employs over 300, including a leadership team that is led by the Faciana’s four children and their spouses. PVC anticipates no changes to its leadership, shareholders or staff throughout the partnership. Dexterra, a publicly traded company, employs more than 9,000 who deliver support services for the management and operation of infrastructure across Canada and the U.S.

    “This partnership with Dexterra will allow us to add a range of resources, expand our technological platform, grow our service offerings for our customers, and scale faster than we could on our own,” said Gino Faciana.

    Co-CEO Barbara Faciana added, “The upside is that this creates benefits for everyone involved. It enhances our service offerings without disrupting existing customer relationships or agreements, while also creating new opportunities for our employees to grow and collaborate with the Dexterra team.”

    “We are excited to announce our investment in PVC,” said Mark Becker, Chief Executive Officer, Dexterra Group. “PVC’s reputation, culture, and values align very well with Dexterra. Their capabilities and market focus both complement and build our U.S.-based platform supporting long-term profitable growth. The Faciana family will continue to manage the business, and we are looking forward to a long and successful working relationship.”

    Information about PVC is available at PleasantValleyCorporation.com. Details about Dexterra are available at Dexterra.com.

    About Pleasant Valley Corporation:
    Pleasant Valley Corporation was founded in 1976 to provide facility management, construction and real estate services across the U.S.

    About Dexterra Group Inc.:
    Powered by people, Dexterra brings best-in-class regional expertise to every challenge and delivers innovative solutions, giving clients confidence in their day-to-day operations. Dexterra employs more than 9,000 people, delivering a range of support services for the management and operation of infrastructure across Canada and the U.S. Activities include a comprehensive range of integrated facilities management services, industry-leading workforce accommodation solutions, and other support services for diverse clients in the public and private sectors.

    Contact Information

    Kurt Kleidon
    President, Kleidon & Associates
    kurt@kleidon.com
    330-666-5984

    .

    SOURCE: Pleasant Valley

    View the original press release on ACCESS Newswire

  • Emergency Commercial Roofing Takes Center Stage in Phoenix with Efficient Roofing’s New Rapid Response Service

    Emergency Commercial Roofing Takes Center Stage in Phoenix with Efficient Roofing’s New Rapid Response Service

    Efficient Roofing, a respected name in the roofing industry, has announced a new service aimed at helping businesses deal with urgent roofing needs. The company now offers emergency commercial roofing in Phoenix, designed to tackle roofing problems quickly and minimize any disruptions to business operations. Find more about their comprehensive commercial roofing services on their website, where they highlight their tailored approach to meet the unique needs of businesses of all sizes.

    Roofing emergencies can hit businesses hard, creating issues that need immediate attention. If these problems aren’t fixed right away, they can lead to bigger damage and safety risks. To address this, Efficient Roofing has a team of experienced professionals ready to provide fast and reliable roofing repairs during emergencies. This ensures that businesses in Phoenix can keep going with as little downtime as possible.

    Efficient Roofing also offers a wide range of roofing solutions, and metal roofing is a standout option. Known for its strength and long life, metal roofing has become a favorite among commercial clients. By offering a variety of advanced roofing solutions, Efficient Roofing shows its dedication to meeting the different needs of its clients. Details on their metal roofing options illustrate their focus on providing durable, energy-efficient, and low-maintenance roofing systems.

    “Businesses can’t just stop because of unexpected roofing issues,” said the CEO of Efficient Roofing. “Our emergency commercial roofing service in Phoenix is made to respond quickly, making sure all repairs are done in a timely and effective manner to keep businesses running smoothly.”

    The company’s team is skilled in managing various roofing materials and challenges, which ensures a solid approach to every project. Efficient Roofing’s focus on top-notch workmanship provides exact and careful handling of all repairs and installations, building the trust their customers have in them.

    The demand for reliable roofing services is on the rise, driven by unpredictable weather and sudden roof damage. Many business owners are on the lookout for dependable partners who can offer quick and reliable solutions. Efficient Roofing’s new service is an answer to this demand, providing Phoenix business owners with the promise of fast and skillful roof repairs.

    Talking about the benefits of metal roofing, a spokesperson for the company mentioned, “Metal roofing is highly valued for its toughness and ability to stand up against the elements. Our clients see the long-term benefits of this roofing choice, and we stay committed to offering great installations that last for years.”

    Efficient Roofing has built a strong reputation for quality and dependability, continually striving to uphold high standards in every project. Whether it’s a small repair or a complex undertaking, the company focuses heavily on detail, making sure customer satisfaction is front and center. This new emergency service shows their continuing commitment to going beyond client expectations. Explore their roof repairs page to understand how they ensure longevity and quality in their repair services.

    Businesses in Phoenix can rely on Efficient Roofing to capably handle urgent roofing challenges. By offering exceptional service, the company makes sure clients are attended to quickly without lowering the quality of work.

    Additionally, Efficient Roofing’s ability to adapt and broaden its services shows how they can customize solutions to meet specific needs. Whether it’s about fixing urgent problems or choosing durable options like metal roofing, Efficient Roofing stands as a trustworthy partner for businesses aiming to protect their buildings.

    With service upgrades like these, Efficient Roofing positions itself as a vital resource for commercial clients in Phoenix. These efforts reflect the company’s proactive approach to changing client needs, allowing them to provide not only immediate help but also long-term roofing strategies that support businesses well into the future. Visit their website to learn more about their commitment to quality and customer satisfaction across a variety of roofing solutions.

  • Lex Wire Journal Launches to Help Attorneys Gain Visibility in AI-Powered Legal Search

    Lex Wire Journal Launches to Help Attorneys Gain Visibility in AI-Powered Legal Search

    As artificial intelligence tools increasingly shape how legal professionals are discovered and cited, a new legal publishing platform has launched with the goal of helping attorneys adapt to a changing digital information ecosystem. Lex Wire Journal, a newly introduced media outlet headquartered in Dallas, Texas, aims to support law firms, solo practitioners, and legal institutions in achieving lasting online visibility through structured, AI-readable content.

    Founded by attorney and legal strategist Jeff Howell, Esq., Lex Wire Journal enters the market at a time when search engines are transitioning from traditional keyword indexing to entity-based citation systems. The platform is positioned as a digital legal news publication, not a marketing agency, and was built to address a specific challenge: ensuring attorneys can be found, cited, and trusted by the machines that increasingly influence how people interact with legal information online.

    Howell, who has worked at the intersection of law, technology, and digital publishing for over a decade, developed the concept for Lex Wire Journal after observing growing changes in how platforms such as Google Search Generative Experience (SGE), Microsoft Copilot, ChatGPT, and Perplexity AI surface legal expertise. According to Howell, the legal industry is in the midst of a visibility shift that few practitioners are prepared for.

    “In the past, attorneys relied on referrals, verdicts, or even search rankings to be discovered by clients and peers,” Howell said. “Today, AI tools are the first stop for many people seeking legal information. These systems don’t just scrape websites. They cite structured content that meets specific machine-readable criteria. If you’re not publishing in a way that’s compatible with AI discovery, you’re essentially invisible to a large portion of your future audience.”

    Lex Wire Journal was developed as a solution to this issue. The platform serves as a centralized publishing destination where attorneys can contribute original articles, case commentaries, legal news analysis, and press releases. All content is reviewed editorially and formatted according to standards that optimize it for both human readers and artificial intelligence systems.

    At the core of the platform is a belief that structured content is the foundation of long-term digital authority. To that end, Lex Wire Journal incorporates schema markup such as LegalService, NewsArticle, and Review schema into each article published. This approach enables machines to interpret not only the topical relevance of the content but also the professional credentials of the authors involved.

    In contrast to traditional legal blogs or firm-run news sections, Lex Wire Journal operates under a third-party editorial model. Each piece is attributed to a bar-verified attorney, when applicable, and includes disclaimers to clarify jurisdictional relevance and legal ethics considerations. The platform does not accept or promote opinion pieces, advertorials, or self-promotional content. Instead, the focus is on publishing credible, objective, and jurisdictionally aware legal journalism that enhances trust in the attorney’s professional voice.

    The platform’s official launch includes several digital products designed to support ongoing content visibility for its contributors. These include a legal audio interview series focused on AI and the legal profession, a weekly newsletter highlighting key updates in legal technology and visibility strategy, and a structured syndication service that distributes attorney-authored content to trusted directories, Substack feeds, and selected legal media partners. Each distribution path is selected for its compatibility with citation-based AI tools.

    The founding of Lex Wire Journal reflects a broader change occurring across the legal marketing and publishing industries. As large language models increasingly power consumer research, in-house counsel decisions, and journalist inquiries, the ability to appear as a trusted source in those systems is becoming a measurable competitive advantage. Firms that continue to rely solely on SEO or paid advertising may struggle to maintain visibility, especially as user behavior moves toward conversational and voice-driven interfaces.

    Legal technology experts have pointed to a fundamental evolution in how content is ranked and surfaced. Where previous models focused on inbound links and keyword frequency, today’s algorithms evaluate the presence of structured data, contextual relevance, citation trustworthiness, and author reputation. Lex Wire Journal is positioned as a platform that helps attorneys adapt to these emerging standards without compromising on ethics, tone, or compliance.

    The platform also seeks to assist legal institutions, such as bar associations, law schools, and professional groups in publishing public-interest articles and jurisdiction-specific legal insights. According to Howell, one of the long-term goals of Lex Wire Journal is to serve as a digital legal review of sorts, but one optimized for the 21st-century information environment.

    “We are creating a platform that’s designed for citation by both people and machines,” Howell said. “That means it must be neutral, structured, and verifiable. We are not interested in hype or opinion. Our job is to help attorneys speak in a format that AI tools can trust.”

    The platform’s editorial process includes internal fact-checking, source verification, and content review to ensure that each publication meets industry and ethical standards. Articles are reviewed by legal editors, and contributors are required to submit a short verification form confirming their bar membership and jurisdiction of practice. These measures are designed to ensure the integrity and reliability of the platform’s content while preventing misuse or misrepresentation.

    The Lex Wire Journal website includes a growing archive of original publications, a contributor portal for attorney-authors, and guidance on structured writing formats. Attorneys interested in publishing through the platform must meet eligibility criteria and adhere to the journal’s publication standards, which emphasize objectivity, third-person narrative, citation integrity, and relevance to current legal developments.

    Howell emphasized that the platform is not intended to replace traditional legal scholarship or courtroom advocacy, but to complement it by offering a new channel through which attorneys can demonstrate expertise in the digital landscape. By appearing in a structured, trusted publication that integrates with modern discovery tools, lawyers increase the chances that their insights will be surfaced when AI tools respond to legal queries, summarize expert opinions, or compile jurisdictional guidance.

    The platform does not sell advertising, offer client leads, or publish marketing claims. Its business model is based on content review, publication, and structured distribution services that help authors maintain digital credibility. Howell notes that this distinction is important, particularly as regulators and legal ethics committees begin to evaluate how AI-driven publishing intersects with attorney advertising rules.

    “Our goal is to stay well within the lines of bar compliance while pushing the boundaries of what’s possible with legal publishing in a machine-learning world,” Howell said. “Attorneys deserve to be discoverable, not because they advertised the most, but because their work is structured, verified, and worthy of citation.”

    With its official launch, Lex Wire Journal now joins the small but growing cohort of legal media companies that are aligning themselves with the needs of artificial intelligence systems, while maintaining rigorous editorial standards. As the legal profession continues to evolve alongside advances in technology, platforms like Lex Wire Journal may play an increasingly central role in shaping how expertise is demonstrated, distributed, and trusted.

    For attorneys seeking to publish, be cited, or simply remain visible in a rapidly changing information environment, Lex Wire Journal offers a forward-thinking solution built specifically for this purpose.

    Lex Wire Journal is a digital legal news publication designed to help attorneys and law firms achieve structured visibility in the age of AI-powered search and machine-based legal discovery. The platform publishes bar-compliant legal articles, structured press releases, and jurisdictionally aware commentary, all optimized for citation by AI tools and modern search engines. Lex Wire Journal was founded by attorney Jeff Howell, Esq., and operates as a third-party media platform for the legal profession.

  • T.D.E. Wedding Expands as Leading Chinese Wedding Planner in San Francisco: Embracing Tradition with Personalized Touch

    T.D.E. Wedding Expands as Leading Chinese Wedding Planner in San Francisco: Embracing Tradition with Personalized Touch

    T.D.E. Wedding, well known for its event planning services, has announced an expansion aimed at meeting the needs of clients who want unique wedding experiences. With a focus on cultural inclusivity and personalized service, T.D.E. Wedding is reaching out to broader audiences. The company is particularly interested in helping couples blend traditional and contemporary styles into their ceremonies.

    A key focus for T.D.E. Wedding is the Chinese wedding market in San Francisco. As a top Chinese wedding planner in San Francisco, the company understands the complexity and richness of Chinese wedding traditions. They have made sure their planners are knowledgeable about these customs. From intricate tea ceremonies to lively receptions, T.D.E. Wedding provides expert advice in crafting meaningful and authentic ceremonies. Incorporating traditional Chinese elements adds depth to any wedding, and T.D.E. Wedding aims to make this process smooth for every couple.

    Potential clients can explore the comprehensive wedding planning services offered by T.D.E. Wedding on their official website, which provides detailed information about their all-inclusive packages and additional offerings like photography, makeup, and floral arrangements.

    Otis Fang of T.D.E. Wedding shared, “We aim to give all couples a wedding that mirrors their cultural background and personal style. Expanding to be the leading Chinese wedding planner in San Francisco is a major step towards this goal. We want every couple to receive personalized care and a celebration that respects their heritage.”

    Beyond Chinese weddings, T.D.E. Wedding offers services that honor a variety of cultural backgrounds. This effort is part of a larger goal to make weddings more inclusive and reflective of the couple’s traditions. Each service is customized to meet the specific needs of the client, highlighting a commitment to personalized attention.

    Otis Fang added, “Understanding our clients’ traditions is key to providing a memorable experience. We collaborate closely with each couple to ensure their wedding day aligns with their vision, integrating traditional and modern elements. Our team is passionate about making each wedding truly reflect the couple’s journey.”

    By offering these tailored services, T.D.E. Wedding not only meets the growing demand for culturally-rich ceremonies but also sets a high standard in the wedding planning industry. Their professionals are trained to appreciate various cultural practices to ensure every event is as genuine as possible. This dedication defines the company’s mission.

    For those interested in unique offerings like their photo-booth services or to learn more about their event lighting options, visiting their website will provide detailed insights into how T.D.E. Wedding can enhance the atmosphere of any wedding.

    The expansion also leads to T.D.E. Wedding investing in resources and tools that support culturally specific ceremonies. This includes working with vendors who specialize in traditional elements, ensuring each detail of the wedding day is attended to with care. With this approach, couples can relax knowing their special day is in the hands of experts who respect their cultural needs.

    Couples who choose T.D.E. Wedding can look forward to a stress-free experience from beginning to end. The process is built on strong communication, ensuring that each wedding unfolds flawlessly, allowing clients to enjoy their day without worries.

    Through this expansion, T.D.E. Wedding stands out as a leader in culturally-inclusive wedding planning. Whether it’s a traditional Chinese wedding or any cultural celebration in San Francisco, T.D.E. Wedding is dedicated to crafting a ceremony that is both unique and personal. By committing to authenticity and personal service, T.D.E. Wedding continues to create weddings that are both memorable and meaningful.

    As the company moves forward, T.D.E. Wedding is committed to serving the diverse needs of couples who want to merge tradition with their own personal touches. As a notable Chinese wedding planner San Francisco, their mission aligns with a wider trend in the wedding industry toward inclusivity and cultural respect, emphasizing the significance of personalized service in creating truly unforgettable celebrations.

  • Cool Blew Inc. Expands Emergency Commercial AC Repair Services in Goodyear

    Cool Blew Inc. Expands Emergency Commercial AC Repair Services in Goodyear

    Cool Blew Inc., a family-run business based in Peoria, Arizona, has been serving the community since 2002. They have announced that they’re expanding their emergency commercial AC repair services in Goodyear. This move highlights their dedication to offering top-notch HVAC solutions to businesses around the area. Known for their skill in air conditioning repair, installation, and maintenance, Cool Blew Inc. stands out with its prompt response times and dependable problem-solving for AC issues customers face.

    Scott Proctor, the Operations Manager, shared, “Our main goal is to provide our clients with exceptional service when they need it most. By expanding our emergency commercial AC repair services in Goodyear, we’re reinforcing that promise. We know how a broken AC unit can impact a business, especially with Arizona’s hot weather.”

    The company isn’t stopping there; they are also extending their emergency commercial AC repair in Paradise Valley. Their aim is to offer businesses here the same speedy and efficient service they are known for in other locations. This effort is all about cutting down on downtime and keeping businesses comfortable and running smoothly.

    Scott Proctor commented further, “We’re excited to bring our emergency commercial AC repair to Paradise Valley. Our team of skilled technicians has the know-how and tools to tackle any AC emergency, helping our clients maintain smooth operations with few disruptions.”

    Cool Blew Inc. provides a wide range of HVAC services, including the repair and installation of both residential and commercial air conditioning systems. They also offer heating services and plumbing solutions. As a dealer for well-known brands, they use advanced technology to deliver effective and sustainable solutions. Their 24-hour emergency services ensure businesses can get help whenever it’s needed.

    In Goodyear, businesses now have access to improved services designed to quickly address any air conditioning emergencies. Whether it’s a simple fix or a complicated installation, the team at Cool Blew Inc. brings extensive expertise to every project, ensuring customers are satisfied and relieved.

    A standout feature of their service is the use of the latest technology across all their work. This not only includes their HVAC services but also their wide-ranging solar solutions. As a certified solar panel installer, Cool Blew Inc. offers initial consultations, system design, installation, and repairs, which supports sustainable energy choices for residential and commercial clients alike.

    Additionally, they offer a comprehensive range of plumbing services. This includes everything from fixing leaks and installing water heaters to regular maintenance and emergency help. Together with their HVAC skills, they serve as a versatile provider for homeowners and businesses.

    The company’s focus on quality is evident in their service plans, designed to extend the lifespan of HVAC systems and save customers money on long-term utility costs. Cool Blew Inc. knows how crucial reliable air conditioning is in Arizona, and they aim to provide excellent service with every client interaction.

    Cool Blew Inc. invites businesses in Goodyear and Paradise Valley to get in touch if they need fast and expert AC repair services. With a strong emphasis on customer care and efficient service, Cool Blew Inc. is a trusted name in the HVAC industry, always aiming to meet the needs of their clients across the Valley.

    Cool Blew Inc. is ready to help businesses with their HVAC and plumbing requirements, committed to providing quality solutions in times of need. To explore more about their services, check out their main website.

  • Inspire Veterinary Partners Announces up to $10M in Financing at $1.00 per Share Through Cash and Transferred Securities

    Inspire Veterinary Partners Announces up to $10M in Financing at $1.00 per Share Through Cash and Transferred Securities

    VIRGINIA BEACH, VA / ACCESS Newswire / August 4, 2025 / Inspire Veterinary Partners, Inc. (NASDAQ:IVP) (“Inspire” or the “Company”), an owner and provider of pet health care services throughout the U.S., today announced that it has entered into a securities purchase agreement for the issuance and sale of securities under a new convertible preferred stock transaction. The consideration, consisting of a combination of cash and transferred securities, was valued at $1.00 per share.

    The gross proceeds to the Company from the offering are expected to be up to $10 million, including $6 million expected to be received through the investment of cash and securities at the first closing, and up to $4 million of cash that may be funded at one or more additional closings, at the election of the investors. The Company intends to use the net proceeds from the offering for general working capital and acquisitions of additional veterinary practices. The proceeds will also help to address current Nasdaq deficiencies around Shareholders Equity and extend cash on hand to maintain operations and extend runway.

    “As communicated earlier in 2025, the team at IVP is executing on our growth strategy and this offering helps to facilitate our objectives,” said President, Chairman and CEO, Kimball Carr, “With new acquisitions onboarded and record clinical hiring this year, I could not be prouder of our team for the continued progress being made across all departments within IVP.”

    This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction.

    About Inspire Veterinary Partners, Inc.

    Inspire Veterinary Partners is an owner and provider of pet health care services throughout the US. As the Company expands, it expects to acquire additional veterinary hospitals, including general practice, mixed animal facilities, and critical and emergency care. For more information, please visit: www.inspirevet.com.

    Facebook | LinkedIn | X

    Forward-Looking Statements

    This press release contains forward-looking statements regarding the Company’s current expectations. These statements are not guarantees of future performance and are subject to certain risks, uncertainties and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, statements by the Company relating to the completion of the offering, the satisfaction of customary closing conditions related to the offering, the intended use of proceeds from the offering, receipt of Stockholder Approval as well as risks and uncertainties related to the satisfaction of customary closing conditions related to anticipated acquisitions, or factors that result in changes to the Company’s anticipated results of operations related to acquisitions. These and other risks and uncertainties are described more fully in the section captioned “Risk Factors” in the Company’s public filings made with the Securities and Exchange Commission, including its Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. Forward-looking statements contained in this announcement are made as of this date, and the Company undertakes no duty to update such information except as required under applicable law.

    Investor Contact

    CoreIR
    Matt Blazei
    516-386-0430
    mattb@coreir.com

    Press Contact

    CORE IR
    Matthew Cossel
    pr@coreir.com

    General Inquires

    Morgan Wood
    Mwood@inspirevet.com

    SOURCE: INSPIRE VETERINARY PARTNERS, INC.

    View the original press release on ACCESS Newswire

  • Phase 1 Clinical Ttrial of HIV Vaccine Starts in Africa to Evaluate Immune Responses to Highly Networked HIV T-Cell Epitopes

    Phase 1 Clinical Ttrial of HIV Vaccine Starts in Africa to Evaluate Immune Responses to Highly Networked HIV T-Cell Epitopes

    Led by a team of African researchers, first doses of the novel T cell-inducing GRAdHIVNE1 vaccine candidate have been given.

    HARARE, ZIMBABWE, ROME, ITALY, NEW YORK, NY, AND CAMBRIDGE, MA / ACCESS Newswire / August 4, 2025 / The Mutala Trust, ReiThera Srl (ReiThera), the Ragon Institute of Mass General Brigham, MIT, and Harvard (the Ragon Institute), and IAVI are pleased to announce that the first doses of an investigational HIV vaccine candidate have been administered. The vaccine candidate, Gorilla Adenovirus Vectored HIV Networked Epitopes Vaccine (GRAdHIVNE1), was first administered on July 28, 2025, at the Mutala Trust clinical trial site in Harare, Zimbabwe. This effort is made possible by a global collaboration and a team of African principal investigators who will lead the clinical research in South Africa and Zimbabwe (listed below). Vaccine immunogenicity will also be assessed locally by a network of state-of-the-art African research institutes: Cape Town HVTN Immunology Laboratory in Cape Town, African Health Research Institute in Durban, and the National Institute for Communicable Diseases in Johannesburg, South Africa.

    This Phase 1, first-in-human clinical trial will enroll approximately 120 healthy adults aged 18-50 years, including 48 people living with HIV who are virally suppressed on antiretroviral therapy (ART). The trial is designed to assess the safety and immunogenicity of the vaccine candidate in people living with and without HIV. Participants will receive either one or two doses of the investigational vaccine or a placebo and will be monitored over a period of 19 months for safety and immune responses.

    This clinical trial, IAVI C114, is sponsored by IAVI. GRAdHIVNE1 has been made possible by a collaborative effort. ReiThera developed the GRAd viral vector platform and manufactured the vaccine candidate, while the Ragon Institute designed the immunogen using novel strategies to identify protective HIV epitopes and facilitate their targeting by T cells. This clinical program is funded by the Gates Foundation.

    The IAVI C114 clinical trial is taking place at three clinical trial sites: the Mutala Trust Clinical Trial Site, in Harare, Zimbabwe; the Desmond Tutu Health Foundation (DTHF), in Cape Town, South Africa; and the Africa Health Research Institute (AHRI), in Durban, South Africa. To determine the vaccine candidate’s potential for relevance in sub-Saharan Africa, where disease burden is greatest, it is essential that the candidate be tested within communities affected by the epidemic.

    “This is a landmark moment for South Africa, Zimbabwe, and the continent. It shows the power of true partnership: IAVI’s sponsorship, ReiThera’s GRAd technology, the Ragon Institute’s innovative immunogen built on decades of science, and African investigators co-leading every phase of the trial. We are edging closer to an HIV vaccine, made possible by global collaboration, with clinical trials conducted in Africa, for Africa, and for the world.” said Dr. Tariro Makadzange, Clinical Trial Lead, Mutala Trust.

    “This trial represents the future of vaccine development, rooted in Africa, built through global partnerships, and designed for the communities most affected by HIV,” said Dr. Vincent Muturi-Kioi, HIV Vaccines Product Development Team Lead at IAVI.

    The vaccine candidate is designed to engage the immune system to recognize and target critical structural regions of HIV using a clinically validated, potent, T cell-inducing GRAd vector. This approach will be evaluated to assess the ability of the vaccine candidate to direct strong CD8+ T cell immune responses towards these vulnerable viral regions.

    “We are thrilled to be moving insights from our long-term studies of spontaneous elite controllers of HIV toward the development of GRAdHIVNE1 and its testing in Africa. We are truly grateful to the network of global and African partners that have come together to make the IAVI C114 trial a reality,” said Dr. Gaurav Gaiha, Associate Professor of Medicine at Harvard Medical School and Principal Investigator at the Ragon Institute of Mass General Brigham, MIT, and Harvard.

    Because CD8+ T cells induced by this vaccine hold promise for targeting HIV-infected cells, this clinical trial will also assess the safety and immune response in people living with HIV. These data will be used to assess the suitability of the vaccine candidate for the development of investigational HIV therapeutic and curative interventions.

    “We are enormously pleased with the launch of this Phase 1 trial representing the result of a successful global partnership,” said Stefano Colloca, CEO and co-Founder of ReiThera. “This candidate HIV vaccine, built on our GRAd platform, holds great promise to trigger a strong CD8 response targeting vulnerable viral regions.”

    Principal Investigators Leading Clinical Trial Sites:

    • Tariro Makadzange, Mutala Trust

    • Theodorah Rirhandzu Ndzhukule, DTHF

    • Limakatso Lebina, AHRI

    About IAVI

    IAVI is a global nonprofit scientific organization that works to develop vaccines and antibodies to prevent HIV and other infectious diseases, with a focus on innovation and equitable access. IAVI is the sponsor of this trial. Read more at www.iavi.org.

    IAVI media contact

    Heather Teixeira
    hteixeira@iavi.org

    About Mutala Trust

    Mutala Trust is founding member of Africa Clinical Research Network (ACRN) and is a site based in Harare, Zimbabwe. It is known for conducting high-quality, ethically sound clinical trials addressing diseases that affect African communities. Mutala is the clinical lead site for the study.

    Mutala Trustmedia contact

    coms@acrnhealth.com

    About ReiThera Srl.

    ReiThera Srl, an Italian CDMO specializing in technology and process development as well as GMP manufacturing of viral vectors for genetic vaccines and advanced therapies, is the developer and owner of the GRAd platform used for this HIV vaccine.

    ReiThera media contact

    communication@reithera.com

    About the Ragon Institute of Mass General Brigham, MIT, and Harvard

    The Ragon Institute of Mass General Brigham, MIT, and Harvard was established with a collaborative scientific mission among these institutions that brings scientists, clinicians and engineers together to harness the immune system to combat and cure human disease. They contributed to vaccine design. For more information, visit www.ragoninstitute.org

    Ragon Institutemedia contact

    ragoncommunications@mgh.harvard.edu

    SOURCE: IAVI

    View the original press release on ACCESS Newswire

  • IRS Begins Scrutinizing “Cash-Only” Businesses in 2025 – Clear Start Tax Shares What to Expect

    IRS Begins Scrutinizing “Cash-Only” Businesses in 2025 – Clear Start Tax Shares What to Expect

    New IRS enforcement initiative targets restaurants, salons, and other cash-heavy operations as audit risk rises in 2025

    IRVINE, CA / ACCESS Newswire / August 4, 2025 / The IRS is ramping up its scrutiny of “cash-only” businesses in 2025, renewing enforcement efforts aimed at industries known for limited electronic records and underreported income. Restaurants, barbershops, nail salons, convenience stores, and similar businesses could face increased audit activity, according to tax professionals closely following the agency’s shift.

    Clear Start Tax, a national tax resolution firm, is advising small business owners who rely on cash transactions to take proactive steps to ensure their books are in order and avoid unnecessary penalties.

    “The IRS is targeting businesses with high cash volume because they often lack digital documentation, which makes them easier to flag for underreporting,” said a spokesperson for Clear Start Tax. “This year, the agency has new tools and data analytics that make it much easier to spot discrepancies in cash-heavy operations.”

    The enforcement push comes as part of a broader IRS strategy to close the “tax gap” – the difference between taxes owed and taxes actually collected – with the help of increased funding and advanced AI audit filters. Officials have stated they will focus on industries with historical patterns of noncompliance, particularly where income may be hidden or underreported.

    “We’re seeing a clear pattern: if your business isn’t using point-of-sale systems or bank deposits to track revenue, you’re at greater risk,” the Clear Start Tax spokesperson added. “Even businesses that aren’t intentionally evading taxes could get caught up in this if their recordkeeping is sloppy or inconsistent.”

    Clear Start Tax recommends that cash-based businesses conduct internal reviews, reconcile deposits with reported income, and consider working with professionals to prepare for potential audits. The firm has already seen a rise in inquiries from business owners seeking advice on how to respond to IRS notices or suspected underreporting claims.

    “Our message is simple – don’t wait for a letter from the IRS. Get ahead of it,” said the spokesperson. “A few small adjustments in how you document income today could save you thousands down the line.”

    By answering a few simple questions, taxpayers can find out if they’re eligible for the IRS Fresh Start Program and take the first step toward resolving their tax debt.

    The IRS has not announced specific audit targets, but experts say businesses operating with limited digital financial trails are already on the radar.

    About Clear Start Tax

    Clear Start Tax is a trusted tax resolution firm helping individuals and businesses nationwide resolve IRS debt, navigate audits, and find relief through established IRS programs. With a focus on transparency, compliance, and results, the firm has assisted thousands of taxpayers in regaining control of their financial futures.

    Need Help With Back Taxes?

    Click the link below:
    https://clearstarttax.com/qualifytoday/
    (888) 710-3533

    Contact Information

    Clear Start Tax
    Corporate Communications Department
    tech@clearstarttax.com
    (949) 800-4011

    SOURCE: Clear Start Tax

    View the original press release on ACCESS Newswire

  • Tharimmune Issues Comprehensive Corporate Update including Lead TH104 as Critical National Security Solution Against Weaponized Fentanyl and TH023 Poised to Revolutionize Oral Antibody Delivery

    Tharimmune Issues Comprehensive Corporate Update including Lead TH104 as Critical National Security Solution Against Weaponized Fentanyl and TH023 Poised to Revolutionize Oral Antibody Delivery

    -Company closes approximately $5.47 million in equity financing in 2Q/3Q25
    -TH104 potentially fills a critical National Security Need against Weaponized Fentanyl
    TH023 may fulfill the promise of delivering a safe and effective oral antibody medication against inflammation
    -Company Strengthens Operational Leadership, Corporate Governance and Accounting

    RED BANK, NJ / ACCESS Newswire / August 4, 2025 / Tharimmune, Inc. (Nasdaq:THAR) (“Tharimmune” or the “Company”), a clinical-stage biotechnology company dedicated to developing innovative therapeutic candidates for inflammation, immunology, and critical unmet medical needs, today issued a comprehensive corporate update highlighting significant advancements across its pipeline. The update underscores the rapid progression of TH104 as a lead asset addressing critical national security risks posed by weaponized fentanyl, and the transformative potential of TH023 in pioneering oral antibody delivery for widespread inflammatory conditions.

    The Company has strengthened its financial position by successfully completing several equity financings and securing approximately $5.47 million in gross proceeds before deducting placement and legal fees, during the latter part of the second quarter and continuing into the third quarter of this year. The capital infusion underscores the strong confidence from existing investors, whose continued commitment reflects a clear recognition of the Company’s strategic vision and pipeline potential. We believe these proceeds will strategically accelerate the advancement of TH104, recognizing its paramount importance as a swiftly progressing national security asset, in addition to supporting general corporate purposes vital for the Company’s continued growth and operational efficiency.

    “Over the past year, Tharimmune has achieved considerable milestones, particularly in advancing our lead candidate TH104 to a potential NDA with clear direction from FDA on a pathway while demonstrating preclinical success with our oral antibody program, TH023,” stated Sireesh Appajosyula, Chief Executive Officer of Tharimmune. “Our strategic focus on high-impact solutions, from protecting military and first responders to redefining treatment paradigms for chronic inflammatory diseases, reflects our unwavering commitment to patient well-being and shareholder value.”

    TH104: A National Security Solution Against Weaponized Fentanyl and High-Potency Opioids

    Tharimmune’s lead asset, TH104, a buccal film formulation of nalmefene, has rapidly advanced with a regulatory pathway to address the escalating national security threat posed by weaponized fentanyl and other high-potency opioids like fentanyl.

    Addressing an Important National Security Threat: The U.S. government has increasingly recognized fentanyl and its related compounds as significant national security threats due to their extreme potency and potential for mass casualty incidents if weaponized. Incidents such as the 2002 Moscow theater hostage crisis, where aerosolized synthetic opioids were reportedly used, tragically demonstrated the devastating potential of such agents. In this critical context, Tharimmune explicitly positions TH104 as a direct response to this growing threat, aligning with the urgent need for specialized prophylactic medical countermeasures highlighted in recent U.S. Strategic National Stockpile (SNS) market assessments.

    Superiority and Convenience over Current Solutions: While existing solutions like naloxone auto-injectors are vital for emergency reversal, they often have a relatively short half-life (e.g., naloxone has a half-life of approximately 60-90 minutes to 2 hours). This can necessitate repeated dosing, particularly with longer-acting or highly potent synthetic opioids like fentanyl, which can have a significantly longer half-life (around 8 hours). TH104, which utilizes nalmefene, offers a crucial advantage with a significantly longer plasma half-life of approximately 8 to 11 hours. This extended duration of action means TH104 provides sustained protection, potentially reducing the need for continuous monitoring and potential multiple redosing in a high-risk environment. Furthermore, TH104’s buccal film formulation allows for rapid and convenient administration, a critical benefit for military personnel and chemical incident responders who may be wearing full protective gear, where intramuscular injections can be impractical or delayed.

    Positive FDA Feedback and Expedited Pathway: In a pivotal development, Tharimmune previously announced positive feedback from the FDA regarding the New Drug Application (NDA) path for TH104. Crucially, the FDA confirmed that no additional clinical trials appear to be necessary prior to a 505(b)(2) NDA submission for TH104’s proposed indication: “Temporary Prophylaxis of Respiratory and/or Nervous System Depression in Military Personnel and Chemical Incident Responders Entering an Area Contaminated with High-Potency Opioids.” This expedited pathway allows Tharimmune to leverage existing extensive safety and efficacy data for nalmefene, combined with the Company’s human pharmacokinetic data, enabling an “in silico” (computer simulation) submission model, significantly accelerating its potential availability.

    Robust Clinical Data and Metabolic Profile: Positive Phase 1 clinical data for TH104, presented at prominent conferences including Digestive Disease Week (DDW) and the European Association for the Study of the Liver (EASL) International Liver Congress in May 2025, highlights its distinct pharmacokinetic and metabolic profile. The data demonstrated that buccal administration achieves systemic exposure to nalmefene with reliable and predictable absorption and delayed phase 1 metabolism, potentially offering advantages for individuals with impaired liver function as potential added benefit. This scientific validation underpins TH104’s suitability as a critical medical countermeasure.

    Strengthened Expertise in National Security: Tharimmune has strategically fortified its leadership to advance TH104’s national security mission. James Gordon Liddy (CDR US Navy SEAL (Ret)), a renowned counter-terrorism and critical infrastructure expert, has been appointed to the Board of Directors and serves as a Key Strategic Advisor. His unparalleled expertise in national security and preparedness, including his role in designing and coordinating policy for the Global War on Terrorism and architecting the Navy’s Anti-Terrorism Force Protection Plan, provides invaluable guidance for the development and potential deployment of TH104 within national security frameworks.

    The Promise of Oral Antibody Delivery

    The administration of monoclonal antibodies (mAb), while highly effective for a range of chronic diseases, has historically been limited to intravenous (IV) infusions or subcutaneous injections. These parenteral routes often necessitate frequent clinic visits, specialized medical personnel for administration, and can be painful or inconvenient for patients, impacting adherence to long-term therapy. The development of an effective oral delivery method for antibodies would truly be a “game-changer,” revolutionizing patient access, convenience, and quality of life by transforming a complex, clinic-bound procedure into a simple, at-home pill. Overcoming the formidable physiological barriers of the gastrointestinal tract – including harsh pH environments, enzymatic degradation, and limited permeability for large molecules – has been a persistent challenge in biopharmaceutical development. We believe Tharimmune’s TH023 program is at the forefront of addressing this critical unmet need.

    TH023: Pioneering Oral Antibody Delivery for Inflammatory Conditions

    Tharimmune is developing TH023, a novel oral monoclonal antibody targeting Tumor Necrosis Factor-alpha (TNF-alpha), licensed through Intract Pharma (UK), which could potentially revolutionize the delivery of biologic therapies for a wide array of inflammatory conditions.

    Preclinical Validation: In an advancement for oral antibody delivery, Tharimmune in the past year announced positive preclinical results for TH023. Leveraging a proprietary protease enzyme stabilized platform (Soteria®), preclinical studies in a murine model successfully demonstrated oral delivery of infliximab, achieving serum concentrations significantly higher than standard therapeutic levels. The studies confirmed enzymatic protection and successful in vivo delivery to both local colonic tissue and systemic circulation, highlighting its potential for treating both local gastrointestinal diseases (like Inflammatory Bowel Disease) and systemic inflammatory conditions. This proprietary formulation showed superior tissue penetration compared to traditional permeation enhancers, underscoring the innovative nature of TH023.

    Revolutionizing Patient Care and Market Potential: This program originated from a strategic global licensing agreement with Intract Pharma for INT-023 (now TH023) in September 2024. Traditionally, TNF-alpha inhibitors like infliximab (Remicade®) are administered via intravenous infusions or subcutaneous injections, which may be burdensome for patients. TH023 aims to overcome these challenges, offering a convenient oral pill form that could dramatically improve patient compliance, quality of life, and reduce healthcare system burdens. With the global infliximab market in the multibillions, an oral formulation represents a substantial commercial opportunity by providing a differentiated, patient-preferred option that broadens access and potentially lowers overall treatment costs.

    Future Development: Building on these promising preclinical results, Tharimmune plans to optimize TH023’s formulation and dosing regimen and prepare for a first-in-human clinical trial within the next 12 months, marking a significant step towards bringing this transformative therapy to patients.

    Strengthening Corporate Governance and Leadership for Accelerated Growth

    Tharimmune has strategically enhanced its leadership and governance structure to support its ambitious pipeline advancements and future growth.

    Key Executive and Board Appointments: In addition to the strategic advisory role and Board appointment of James Gordon Liddy, Tharimmune has appointed Sireesh Appajosyula as Chief Executive Officer, leveraging his extensive experience in corporate development and operations. Vincent LoPriore, with decades of financial and investment banking experience, has been appointed Executive Chairman of the Board, further solidifying strategic oversight. The Board has also been strengthened by the appointments of Clay Kahler, bringing entrepreneurial leadership and expertise in life sciences manufacturing and clinical innovation, and Gary Stetz, a seasoned financial executive with extensive experience in accounting, finance, and corporate governance. These appointments collectively enhance the company’s operational, financial, and strategic capabilities as it advances its critical programs.

    Tharimmune remains dedicated to leveraging its innovative platforms to address high unmet medical needs and drive significant value for patients and shareholders alike.

    About Tharimmune, Inc.

    Tharimmune is a clinical-stage biotechnology company developing a diverse portfolio of therapeutic candidates in immunology, inflammation and oncology. Its lead clinical asset, TH104, is being developed for a specific indication via a 505(b)2 pathway for respiratory and/or nervous system depression in military personnel and chemical incident responders who may encounter environments contaminated with high-potency opioids. The expanded pipeline includes other indications for TH104, such as chronic pruritus in primary biliary cholangitis and TH023, a new approach to treating autoimmune diseases along with an early-stage multispecific biologic platform targeting unique epitopes against multiple solid tumors through its proprietary EpiClick Technology. The Company has a license agreement with OmniAb, Inc. to access their antibody discovery technology for targeting specified disease markers. Tharimmune continues to position itself as a leader in patient-centered innovation while working to deliver long-term value for shareholders. For more information, visit: www.tharimmune.com.

    Forward Looking Statements

    Certain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, contained in this press release, including statements regarding the timing and design of Tharimmune’s future Phase 2 trial, Tharimmune’s strategy, future operations, future financial position, projected costs, prospects, plans and objectives of management, are forward-looking statements. The words “anticipate,” “believe,” “continue,” “could,” “depends,” “estimate,” “expect,” “intend,” “may,” “ongoing,” “plan,” “potential,” “predict,” “project,” “target,” “should,” “will,” “would,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. The Company may not actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements. Factors that may cause such differences, include, but are not limited to, those discussed under Risk Factors set forth in our Annual Report on Form 10-K for the year ended December 31, 2024 and other periodic reports filed by the Company from time to time with the Securities and Exchange Commission. In addition, the forward-looking statements included in this press release represent the Company’s views as of the date of this release. Subsequent events and developments may cause the Company’s views to change; however, the Company does not undertake and specifically disclaims any obligation to update or revise any forward-looking statements to reflect new information, future events or circumstances or to reflect the occurrences of unanticipated events, except as may be required by applicable law. These forward-looking statements should not be relied upon as representing the Company’s views as of any date subsequent to the date of this release.

    Contacts:

    Tharimmune, Inc.
    ir@tharimmune.com

    SOURCE: Tharimmune Inc.

    View the original press release on ACCESS Newswire

  • Pantomath Raises $30 Million in Series B Led by General Catalyst to Automate Data Operations with AI DRE Agent

    Pantomath Raises $30 Million in Series B Led by General Catalyst to Automate Data Operations with AI DRE Agent

    The funding accelerates the company’s mission to eliminate manual data operations by combining real-time monitoring, traceability and agentic AI to boost enterprise data reliability at scale.

    CINCINNATI, OH / ACCESS Newswire / August 4, 2025 / Pantomath, an AI-powered automated data operations platform, today announced it has secured $30 million in Series B funding to expand beyond traditional data observability to become the Operating System for Data Operations. The round was led by General Catalyst, a global investment and transformation company. Existing investors Sierra Ventures, Bowery Capital and Epic Ventures also participated in the round along with Hitachi Ventures, Cintrifuse Capital and Foster Ventures. This new round follows Pantomath’s $14 million Series A in late 2023 led by Sierra Ventures and will accelerate product innovation, go-to-market expansion, and strategic hiring to meet surging enterprise demand to automate manual tasks with AI DRE (Data Reliability Engineer) agents.

    “Enterprises today grapple with highly manual and reactive data operations to support their data pipelines and analytics products. 74% of organizations rely on downstream end-users to discover data reliability problems, leading to isolated manual troubleshooting and incident management that according to a CDO survey takes 90% of organizations hours to weeks to resolve. Data downtime, unreliable data, and failure to meet SLAs are common occurrences in large enterprises,” said Somesh Saxena, co-founder and President of Pantomath who lived through these challenges as a data leader at General Electric prior to co-founding Pantomath in 2022.

    “Our current foundation of auto-discovered data health graphs that automates cross-platform data monitoring positions us well to expand beyond real-time detection of data issues into full self-resolution of incidents with autonomous AI DRE agents,” said Shashank Saxena, co-founder and CEO of Pantomath.

    Since its initial product launch in 2023, Pantomath has experienced rapid growth across industries and now supports mission-critical analytics pipelines at leading Fortune 500 companies. “Pantomath slashed the time our teams spent tracking down broken pipelines. With their automated root-cause analysis, we resolve issues in minutes (not hours, days or weeks) so our business partners always have trusted data. Our data operations teams start and end their day with Pantomath,” said Andrew Connolly, Director of Site Reliability Engineering, WEX.

    The company also announced that Quentin Clark, a Managing Director at General Catalyst, is joining its board of directors. At General Catalyst, Clark has helped scale companies such as Glean, Windsurf (acquired by Cognition), and Neon (acquired by Databricks). “Enterprise data operations have remained stubbornly complex despite years of tooling. Pantomath is changing that with AI-native enterprise software that doesn’t just surface problems, it solves them. This is a shift from software as a passive tool to software that enacts work across the enterprise,” said Clark. “It’s the systems-of-record to systems-of-work transformation we’ve long envisioned.”

    About Pantomath

    Pantomath delivers automated data operations for modern enterprises, unifying real-time monitoring, cross-platform lineage, AI-driven root-cause and impact analysis into a single platform. By eliminating manual troubleshooting and reducing data downtime, Pantomath restores trust in data and unlocks productivity across analytics teams. The company is headquartered in Cincinnati, Ohio. Learn more at pantomath.com.

    About General Catalyst

    General Catalyst is a global investment and transformation company that partners with the world’s most ambitious entrepreneurs to drive resilience and applied AI.

    We support founders with a long-term view who challenge the status quo, partnering with them from seed to growth stage and beyond.

    With offices in San Francisco, New York City, Boston, Berlin, Bangalore, and London, we have supported the growth of 800+ businesses, including Airbnb, Anduril, Applied Intuition, Commure, Glean, Guild, Gusto, Helsing, Hubspot, Kayak, Livongo, Mistral, Ramp, Samsara, Snap, Stripe, Sword, and Zepto.

    For more: www.generalcatalyst.com, @generalcatalyst

    Media Contact:

    Nina Pfister
    MAG PR on behalf of Pantomath
    E: nina@mooringadvisorygroup.com

    SOURCE: Pantomath

    View the original press release on ACCESS Newswire